In most professional cases, yes. Commercial filming, photo shoots, fashion campaigns, beauty films, branded content, luxury commercials and editorial productions in Portofino usually require permission if they involve professional equipment, public-space use, crew activity, tripods, lighting, vehicles, boats, drones, models, talent or brand/commercial usage.
The exact permit depends on the location and production footprint. Shooting in the Piazzetta, Via Roma, Calata Marconi, Molo Umberto I, Marina di Portofino, Paraggi, San Fruttuoso, private villas, hotels, restaurants or protected coastal areas may involve different authorities, owners and approval processes. ORBIS checks this before confirming the location.